Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules 76-05-1 | Trifluoroacetic acid, biochemical grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 662699512
Trifluoroacetic acid, biochemical grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 662699512
Medchemexpress LLC Eda-da tfa | 87156-01-2 | 95.0% | 298.22 | 5 MG
EDA-DA is a N-terminally tagged dipeptide probe used to label Peptidoglycan (PG) of bacteria. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- N-terminally tagged dipeptide probe
- Labels peptidoglycan of bacteria
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC L-Tyrosine, L-tyrosyl-L-lysyl-L-tyrosyl- (TFA) | 98.1% | 749.73 | 5 MG
YKYY TFA is a blood pressure-lowering peptide isolated from the digest of Undaria pinnatifida. This peptide acts as an angiotensin I-converting enzyme (ACE) inhibitor with an IC50 of 64.2 μM. It is suitable for use in hypertension research.
- Antihypertensive peptide
- Angiotensin I-converting enzyme (ACE) inhibitor
- Isolated from the peptic digest of wakame Undaria pinnatifida
- For research use only
![Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232164.png-250.jpg)
Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG
PPACK (TFA) is the trifluoroacetate salt of a peptide-based irreversible thrombin inhibitor supplied as a white to off-white solid. It is used in biochemical assays to inhibit thrombin activity and for anticoagulation research.
- Irreversible thrombin inhibitor for biochemical assays.
- High purity of 99.3% as determined by HPLC.
- White to off-white solid form suitable for storage and handling.
- Recommended storage conditions for powder and solvent are provided in the COA.
- Molecular weight 564.99 and formula C23H32ClF3N6O5.
Medchemexpress LLC SRI 31215 TFA 10mM 1mL | 1832686-44-8 | 1 ML
SRI 31215 (trifluoroacetate) is the TFA salt of a small-molecule inhibitor targeting matriptase, hepsin, and hepatocyte growth factor activator (HGFA). Supplied as a 10 mM solution in DMSO (1 mL), it is intended for in vitro research applications.
- Trifluoroacetate salt.
- Matriptase, hepsin, and HGFA inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High reported purity of 98.5%.
- Molecular formula C27H34F3N5O3; molecular weight 533.59 g/mol.
Medchemexpress LLC Dendrotoxin K TFA | 119128-61-9 | 6559.66 | 500 UG
Dendrotoxin K functions as a Kv1.1 channel blocker. It plays a role in determining glutamate release within CA3 neurons by controlling the presynaptic spike waveform in a time-dependent manner.
- Acts as a Kv1.1 channel blocker.
- Influences glutamate release in CA3 neurons.
- Regulates the presynaptic spike waveform in a time-dependent manner.
- Intended for research use only.
Medchemexpress LLC PHF6 TFA | 99.5% | 748.91 | 5 MG
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein.
- Aggregated tau-PHF6 (VQIVYK) TFA potentiates NLRP3 inflammasome expression and autophagy in human microglial cells.
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.7% | 871.94 | 10 MG
6bK TFA is a potent and selective inhibitor of insulin degrading enzyme (IDE) with an IC50 value of 50 nM. It increases circulating insulin in high-fat-fed mice and enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. This product is suitable for type 2 diabetes research.
- Potent and selective inhibitor of insulin degrading enzyme (IDE)
- Increases circulating insulin in high-fat-fed mice
- Enhances glucose tolerance to oral glucose
- Suitable for type 2 diabetes research
- For research use only
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Medchemexpress LLC DX600 TFA | 99.2% | 3074.33 (free acid) | 1 MG
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been observed to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity. It is for research use only.
- Selective ACE2 specific inhibitor
- Does not cross-react with ACE
- Exacerbates diabetes-induced cardiovascular dysfunction
- Increases cardiac and renal NOX activity
Medchemexpress LLC EZM0414 (TFA) | 2411759-92-5 | 95.48% | 514.51 | 50 MG
EZM0414 TFA is the trifluoroacetic acid salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, researched for relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent and selective SETD2 inhibitor
- Orally active
- Inhibits proliferation of MM and DLBCL cell lines
- Shows robust tumor growth regressions in xenograft models
- High oral bioavailability in rats and mice
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.
- Selective Wnt signaling inhibitor.
- Cell-permeable.
- Stapled peptide.
- Inhibits β-catenin-transcription factor interactions.
- Shows anti-proliferation of cancer cells.
- Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
- Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections